|
KMID : 0361020010440070744
|
|
Korean Journal of Otolaryngology - Head and Neck Surgery
2001 Volume.44 No. 7 p.744 ~ p.747
|
|
|
The Prognostic Value of DNA Flow Cytometry in Patients with Early Primary Oral Cavity and Oropharyngeal Squamous Cell Carcinoma
|
|
김민관/Min Gwan Kim
남순열/유승주/정재걸/김상윤/Soon Yuhl Nam/Seung Joo Yoo/Jae Gul Chung/Sang Yoon Kim
|
|
|
Abstract
|
|
|
Backgrounds and Objective: It has been known that tumor size, regional neck metastasis state and tumor thickness are the prognostic factors of oral cavity or oropharyngeal cancer. Additionally, DNA flow cytometry has also been reported to be one
of
the
pronosic factors. We would like to evaluate the prognostic value of DNA flow cytometry in early oral cavity or oropharyngeal squamous cell carcinoma. Materials and Methods: We analyzed the relation between tumor thickness or neck metastasis and
survival
rate in 59 patients with early oral cavity or oropharyngeal cancer. Among those patients, DNA flow cytometry was performed in 28 cases and the prognostic value of the parameters of DNA flow cytometry was analyzed. Results: Overall, a 2-year
survival
rate of the patients was 90.1%. Neither tumor thickness nor neck metastasis state was related to the overall survival rate. Tumor thickness was not related to neck metastasis state, either. Of the parameters of the DNA flow cytometry, only the S
phase
fraction of aneuploidy was related to the overall survival rate (p=0.0288). Also the total proportion of aneuploidy was weakly related to the state of neck metastasis (p=0.0518). Conclusion: These results indicate that DNA flow cytometry can be
used as
a good complementary factor for predicting the overall survival or neck metastasis in patients with early primary oral cavity or oropharyngeal squamous cell carcinoma.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
  
|